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Distribution and excretion in the rat and monkey of [82Br] bromocriptine

SP Markey, RW Colburn, IJ Kopin and RL Aamodt

Radiolabeled bromocriptine was administered to rats and monkeys and its tissue distribution, rate of excretion and metabolism were determined. In both species, [82Br]bromocriptine is predominantly concentrated in the liver, metabolized and then excreted through bile. Extractable free drug is undetectable in blood after 30 min. After 2 hr, the estimated concentration of free drug in rat brain is 2 x 10(-8) M. Terminal phase half-lives of radiolabel excretion were 2.9 days for the rat and 27.3 days for the monkey. The retained organically bound 82Br is present in a form more polar than bromocriptine.

Volume 211, Issue 1, pp. 31-35, 10/01/1979
Copyright © 1979 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics.