JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dajani, E. Z.
Right arrow Articles by Calhoun, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dajani, E. Z.
Right arrow Articles by Calhoun, D. W.

Synergistic actions of propantheline bromide with cimetidine and thiopropazate hydrochloride in the prevention of stress ulcer formation in rats

EZ Dajani, RG Bianchi and DW Calhoun

The effects of propantheline bromide (PB), cimetidine (CM) and thiopropazate hydrochloride (TP) on the course of stress ulcer formation were investigated. Gastric ulcers were induced by subjecting rats to forced exertion. Intragastric administration of PB, CM or TP produced dose-dependent inhibition of gastric ulceration with parallel dose-response curves. PB was found to be 10 times more potent than TP and 44 times more potent than CM. Administration of subtherapeutic doses of PB and TP in combination produced significant synergistic antiulcer activity. Similarly, PB significantly potentiated the antiulcer actions of CM. However, TP in combination with CM showed no more than simple additive effects. The basis for these enhanced antiulcer activities is not fully understood, but they may be related to suppression by PB of one or more factors in the pathophysiology of stress ulcer formation separate from those affected by TP and CM. This finding supports the concept that a combination of anticholinergic drugs with either histamine H2 antagonists or with tranquilizers may be very useful in the prevention of stress ulcer disease in man.

Volume 210, Issue 3, pp. 373-377, 09/01/1979
Copyright © 1979 by American Society for Pharmacology and Experimental Therapeutics






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics.