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Isoproterenol excretion and metabolism in the isolated perfused rat kidney

SJ Szefler and M Acara

[3H]isoproterenol excretion and metabolism were studied in the isolated perfused rat kidney using a one-pass, non-recirculating perfusion system with constant infusion rates of [3H]isoproterenol. The [3H]isoproterenol (U/P) to inulin (U/P) ratio was approximately 15 indicating extensive tubular secretion. A major renal metabolite, 3-O- methylisoproterenol, appeared in the urine and renal vein perfusate and also accumulated in the renal tissue. The fractional excretion of isoproterenol decreased with time while fractional excretion of p- aminohippurate remained stable. The observed decreasing urinary clearance and percent extraction of isoproterenol with time may be due to the progressive intrarenal accumulation of 3-O-methylisoproterenol.

Volume 210, Issue 2, pp. 295-300, 08/01/1979
Copyright © 1979 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics.