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Pharmacokinetics and cardiopulmonary effects in dogs of sublingual pirbuterol, a new bronchodilator

JW Constantine, HM McIlhenny and PF Moore

The time course of plasma concentrations of sublingually administered pirbuterol was investigated in anesthetized dogs; there was a dose- related increase in plasma drug concentrations which reached maximum values 1 hr or more after administration. In a second study plasma drug levels were correlated with antagonism of histamine-induced changes in pulmonary compliance and resistance which also reached maximum values 1 hr or more after drug administration, although marked antagonism was apparent at 15 to 30 min; blood pressure was unaltered at any dose level and heart rate was influenced only at the highest dose level. A convenient method for study of the bioavailability of sublingual formulations is described, and the potential usefulness of a sublingual dosage form of pirbuterol is discussed.

Volume 208, Issue 3, pp. 371-376, 03/01/1979
Copyright © 1979 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics.