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Osmotic minipumps for administration of barbital to mice: demonstration of functional tolerance and physical dependence

C Siew and DB Goldstein

Sodium barbital was administered to mice at a constant rate by miniature osmotic pumps implanted subcutaneously. Each pump delivered approximately 0.25 mg/hr. With two pumps per mouse, blood barbital levels of 20 to 30 microgram/ml could be maintained for various periods. Barbital was assayed by gas chromatography. Functional tolerance was shown by a significant decrease in sleep time after a challenge dose of barbital administered 24 hours after withdrawal. Physical dependence was demonstrated by withdrawal hyperexcitability as measured either with pentylenetetrazol or by convulsions elicited by handling.

Volume 204, Issue 3, pp. 541-546, 03/01/1978
Copyright © 1978 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics.