JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Berkowitz, B. A.
Right arrow Articles by Ngai, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berkowitz, B. A.
Right arrow Articles by Ngai, S. H.

Nitrous oxide analgesia: reversal by naloxone and development of tolerance

BA Berkowitz, AD Finck and SH Ngai

The objective of this study was to characterize further the nature of nitrous oxide analgesia and to establish if tolerance to nitrous oxide occurs. Methods for studying the analgesic action of a gas are described. In mice, nitrous oxide is analgesic in the phenylquinone and acetic acid abdominal constriction tests. Aspirin and very high doses of alcohol are also active in these tests; however, only nitrous oxide- induced analgesia is antagonized by narcotic antagonists. These data indicate the mechanism of action of nitrous oxide analgesia differs from that of the other two drugs. Nitrous oxide produced a dose-related analgesic response in rats (ED50, 67%) as measured by the tail-flick method. Naloxone, 5 to 30 mg/kg, also antagonized nitrous oxide analgesia in rats. Lower doses of the antagonist were not effective. Tolerance developed to the effects of nitrous oxide in both rats and mice after prolonged exposure. These data lend support to the hypothesis that nitrous oxide and opiates have a significant pharmacologic resemblance and may ultimately produce similar molecular events in the brain leading to the relief of pain.

Volume 203, Issue 3, pp. 539-547, 12/01/1977
Copyright © 1977 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Palliat MedHome page
J. L Parlow, B. Milne, D. A Tod, G I. Stewart, J. M Griffiths, and D. J Dudgeon
Self-administered nitrous oxide for the management of incident pain in terminally ill patients: a blinded case series
Palliative Medicine, January 1, 2005; 19(1): 3 - 8.
[Abstract] [PDF]

Home page
 Mol. Pharmacol.Home page
S. M. Todorovic, V. Jevtovic-Todorovic, S. Mennerick, E. Perez-Reyes, and C. F. Zorumski
Cav3.2 Channel Is a Molecular Substrate for Inhibition of T-Type Calcium Currents in Rat Sensory Neurons by Nitrous Oxide
Mol. Pharmacol., September 1, 2001; 60(3): 603 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Fujinaga, R. Doone, M. F. Davies, and M. Maze
Nitrous Oxide Lacks the Antinociceptive Effect on the Tail Flick Test in Newborn Rats
Anesth. Analg., July 1, 2000; 91(1): 6 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Fender, M. Fujinaga, and M. Maze
Strain Differences in the Antinociceptive Effect of Nitrous Oxide on the Tail Flick Test in Rats
Anesth. Analg., January 1, 2000; 90(1): 195 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Miyazaki, T. Adachi, J. Utsumi, T. Shichino, and H. Segawa
Xenon Has Greater Inhibitory Effects on Spinal Dorsal Horn Neurons than Nitrous Oxide in Spinal Cord Transected Cats
Anesth. Analg., April 1, 1999; 88(4): 893 - 893.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics.