JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tam, S.
Right arrow Articles by Levine, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tam, S.
Right arrow Articles by Levine, L.

Relationships, among the steroids, of anti-inflammatory properties and inhibition of prostaglandin production and arachidonic acid release by transformed mouse fibroblasts

S Tam, SC Hong and L Levine

Anti-inflammatory steroids inhibit the serum-stimulated prostaglandin synthesis and release of [3H]arachidonic acid by methylcholanthrene- transformed mouse fibroblast, MC5-5. The half-maximal concentration for inhibition of both effects parallels the relative anti-inflammatory potencies of these steroids. The fatty acid cyclooxygenase activities of microsomal fractions isolated from cells that had been pretreated with dexamethasone were similar to the activities of microsomal fractions isolated from untreated cells. Intracellular as well as extracellular levels of prostaglandins in dexamethasone inhibited cells were decreased. The anti-inflammatory steroids seem to be blocking deacylation of the phospholipids or transport of the arachidonic acid, after deacylation to the cyclooxygenase.

Volume 203, Issue 1, pp. 162-168, 10/01/1977
Copyright © 1977 by American Society for Pharmacology and Experimental Therapeutics






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics.