JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iwatsubo, K.
Right arrow Articles by Clouet, D. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwatsubo, K.
Right arrow Articles by Clouet, D. H.

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons

K Iwatsubo and DH Clouet

The action of opiates on electrical activity in nigrostriatal neurons was compared with the actions of known dopamine receptor agonists and antagonists in order to clarify the effects of opiates on postsynaptic dopamine receptors in the striatum. The systemic administration of either morphine or haloperidol increased the rate of spontaneous firing of neurons in substantia nigra. The injection of either drug directly into the caudate nucleus of the striatum also increased the firing rates of nigral neurons. The administration of the opiate antagonist, naloxone, blocked or reversed the action of systemically or locally applied morphine on firing rates, but not those of haloperidol. The dopamine receptor agonists, dopa and apomorphine, decreased the firing rate in nigral neurons and also reversed the stimulation of firing rates by morphine. The agonists were only partially successful in reversing the effects of haloperidol. The differences in the ability of naloxone and dopa to reverse the stimulated firing rates produced by morphine or haloperidol support the hypothesis that opiates do not act directly on the postsynaptic dopamine receptor in the striatum.

Volume 202, Issue 2, pp. 429-436, 08/01/1977
Copyright © 1977 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
D. L. Muller and E. M. Unterwald
D1 Dopamine Receptors Modulate {Delta}FosB Induction in Rat Striatum after Intermittent Morphine Administration
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 148 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. L. Kimmel and S. G. Holtzman
Mu Opioid Agonists Potentiate Amphetamine- and Cocaine-Induced Rotational Behavior in the Rat
J. Pharmacol. Exp. Ther., August 1, 1997; 282(2): 734 - 746.
[Abstract] [Full Text]

Home page
 J PsychopharmacolHome page
A.J. Stoessl
Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders
J Psychopharmacol, January 1, 1989; 3(2): 99 - 120.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics.