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Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response

YH Chang

A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.

Volume 201, Issue 1, pp. 1-7, 04/01/1977
Copyright © 1977 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics.