THE ACTION OF QUININE ON SUGAR MOBILIZATION WITH ITS BEARING ON THE QUESTION OF GLYCOGENOLYSIS

¹ From the Laboratory of Pharmacology of the University of Chicago, Chicago

1. Quinine properly administered is a glycogenolytic agent.

2. Quinine hyperglycemia is the result of a central nervous system disturbance which leads by way of the splanchnic nerves and the normally innervated adrenal glands to lysis of glycogen.

3. In the absence of adrenal innervation quinine produces in most instances hypoglycemia, most likely by virtue of a peripheral depression of glycogenolysis.

4. Quinine produces in most instances examined a rise in alkaline reserve capacity of whole blood along with hyperglycemia in normals and hypoglycemia in animals with denervated adrenal glands.

5. Neither quinine nor epinephrine hyperglycemia can, on the basis of available evidences, be considered dependent upon acidosis.