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Effect of sympathetic blocking agents on the antinatriuresis of reflex renal nerve stimulation

EJ Zambraski, GF Dibona and GJ Kaloyanides

To evaluate the effects of reflex renal sympathetic nerve stimulation on renal tubular sodium handling, clearance studies were performed in anesthetized dogs. With renal perfusion pressure held constant, baroreceptor reflex renal sympathetic nerve stimulation was produced by controlled arterial hemorrhage or carotid sinus perfusion. Significant decreases in urinary sodium excretion occurred in the presence of minor insignificant alterations in renal blood flow and no changes in glomerular filtration rate. Renal alpha adrenergic receptor blockade (phenoxybenzamine) or adrenergic blockade (guanethidine) completely reversed the fall in urinary sodium excretion; this could not be attributed to alterations in glomerular filtration rate or renal blood flow. These studies support the interpretation that adrenergic innervation of the renal tubules is involved in the regulation of renal tubular sodium reabsorption.

Volume 198, Issue 2, pp. 464-472, 08/01/1976
Copyright © 1976 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics.