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Actions of trihexyphenidyl and benztropine on squid axon membranes

CH Wu and T Narahashi

Trihexyphenidyl and benztropine have potent local anesthetic action on squid axon membranes. They suppress the peak transient sodium conductance with ED50 values equal to 1.75 X 10(-4) AND 0.78 X 10(-4) M, respectively, and shift the sodium condu-tance curve along the potential axis in the direction of depolarization by 2.3 and 8.7 mV, respectively. The time for the sodium current to attain its peak is shortened. Steady-state potassium conductance is also suppressed by these drugs and undergoes an inactivation which has a potential- dependence characteristic. The local anesthetic action combined with the anticholinergic action may warrant further study of these two drugs, especially trihexyphenidyl, as a potential antiarrhythmic agent.

Volume 197, Issue 1, pp. 135-141, 04/01/1976
Copyright © 1976 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics.