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Effects of heroin and methadone on plasma cortisol and testosterone

JH Mendelson, RE Meyer, J Ellingboe, SM Mirin and M McDougle

Narcotic addicts self-administered heroin intravenously for 10 days under controlled research ward conditions and were subsequently detoxified with methadone for 7 days. Plasma testosterone levels decreased signifcantly when heroin dosage was between 45 and 65 mg/day contrasted to predrug base-line levels. Testosterone levels remained depressed during methadone withdrawal. No statistically significant changes in a.m. plasma cortisol levels were observed during both heroin acquisition and methadone withdrawal.

Volume 195, Issue 2, pp. 296-302, 11/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.