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A comparison of the potencies of a series of barbiturates at the neuromuscular junction and on the central nervous system

S Lee-Son, BE Waud and DR Waud

The ability of a series of barbiturates to depress the depolarizing action of carbachol at the end-plate of guinea-pig lumbrical muscle was studied. The compounds studied were: amorbarbital, aprobarbital, barbital, barbituric acid, butabarbital, butalbital, dimethylbutylethyl barbituric acid, hexobarbital, mephobarbitak, secobarbital, thiamylal, and thiopental. The depressant activity was sensitive to small changes in structure of the compounds strongly suggesting that a specific receptor site was involved in the interaction of the drug with the tissue. The observed relative potencies on the motor end-plate were compared with their anesthetic potencies assayed on tadpoles. The two potencies went hand-in-hand for all the compounds studied, including the convulsant member of the series.

Volume 195, Issue 2, pp. 251-256, 11/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.