JPET Introducing ALZET?ew Model 2006 Pump

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Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys

PD Walson, KS Marshall, RP Forsyth, R Rapoport, KL Melmon and N Castagnoli

Methyldopate, the ethyl ester hydrochloride salt of alpha-methyldopa (alpha-MD), is used extensively in the treatment of severe hypertension. We have developed a high-pressure liquid chromatographic assay to determine the plasma-time concentrations of alpha-MD after intravenous administration of methyldopate and alpha-MD in the monkey in an effort to evaluate the bioavailability of alpha-MD and the extent of in vivo hydrolysis of the amino ester to the amino acid. The results establish that in this experimental situation methyldopate is not metabolically equivalent to alpha-MD.

Volume 195, Issue 1, pp. 151-158, 10/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.