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*Compound via MeSH
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*CARRAGEENAN GUM
*COLCHICINE
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*Edema

Mechanism of action of colchicine. I. Effect of colchicine and its analogs on the reversed passive Arthus reaction and the carrageenan- induced hindpaw edema in the rat

YH Chang

Colchicine and N-desacetyl-N-methylcolchicine suppressed both the reversed passive Arthus reaction and the carrageenan-induced edema in the rat. Colchicine, 2-desmethyl-colchicine glucoside and trimethylcolchicine acid had no effect on either model of inflammation. The ability or inability of these compounds to suppress the development of experimental inflammation correlated with their antimitotic activities. The findings lend support to the hypothesis that the anti- inflammatory and the antimitotic effects of colchicine may depend on the same basic, biophysical mechanism of action, i.e., the disruption of the microtubules.

Volume 194, Issue 1, pp. 154-158, 07/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


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 Arch DermatolHome page
F. D. Malkinson
Colchicine: New Uses of an Old, Old Drug
Arch Dermatol, July 1, 1982; 118(7): 453 - 457.
[Abstract] [PDF]


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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.