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Immunopharmacological studies using 5-hydroxytryptamine antibody

RA O'Brien, M Boublik and S Spector

An antibody to serotonin (5-HT) was tested on several preparations in which 5-HT is considered to be involved. The antibody was capable of effectively competing with 5-HT receptor sites for free molecules of 5- HT. It inhibited the uptake of 3H-5HT by blood platelets and may explain the reduced endogenous 5-HT concentration in blood platelets of immunized rabbits. The decreased platelet content of 5-HT was substantiated by electron microscopic studies which showed a reduction in the number of 5-HT-containing subcellular storage organelles in platelets from these animals. The 5-HT antibody inhibited the 5-HT- induced contraction of aortic strips in a tissue bath preparation. When given intraventricularly, it inhibited for a time the sedative actions of reserpine thus adding new evidence to the often postulated role of 5- HT in the actions of reserpine.

Volume 194, Issue 1, pp. 145-153, 07/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.