JPET Introducing ALZET?ew Model 2006 Pump

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Pentobarbital pharmacokinetics in the normal and in the hepatectomized rat

FW Ossenberg, M Peignoux, D Bourdiau and JP Benhamou

The pharmacokinetics of pentobarbital, a barbiturate metabolized by the liver, was compared in normal and in hepatectomized rats. The blood concentration time curve following a single intravenous injection of pentobarbital was fitted to a two-compartment open model. Both the volume of the central compartment and the elimination rate constant were significantly reduced in hepatectomized rats. It is concluded that the liver plays a role both in the metabolism and the distribution of pentobarbital.

Volume 194, Issue 1, pp. 111-116, 07/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics






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Molecular Interventions Drug Metabolism and Disposition

Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.