![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
BM Altura
It has been generally assumed that reactivity (or responsiveness) of mammalian microcirculatory blood vessels to vasoactive hormones is not influenced by sex. In view of the paucity of knowledge in this area, the present in vivo studies were initiated to determine the quantitative dose-response relationships (by means of a high magnification image-splitting television microscope recording system) of catecholamines, selected sympathomimetics, neurohypophyseal hormones (NHPH), serotonin and angiotensin on mesenteric arterioles of unpretreated male and female rats and male rats pretreated with single low doses of 17 beta-estradiol (2 and 10 mug/100 g s.c.). The results indicate: 1) dose-response curves for the constrictor catecholamines (epinephrine and norepinephrine) and NHPH (vasopressin, oxytocin, vasotocin) in female rats are significantly shifted in parallel manner to the left of those obtained in male rats; 2) pretreatment of male rats with estrogen results in an enhancement of the constrictor actions of catecholamines, NHPH and phenylephrine; 3) the maximal arteriolar contractile responses (i.e., lumen narrowings) to norepinephrine and phenylphrine were enhanced by pretreatment with estrogen; and 4) dose- response curves for arteriolar constrictions induced by dopamine, serotonin or angiotensin were not affected by sex or estrogen pretreatment. The sex-linked differences, observed in this study, thus appear to be specific for NHPH and certain alpha adrenergic agonists. Overall, these findings reinforce the concept that sex hormones may play a role in control of peripheral blood flow and reactivity of arteriolar smooth muscle.
This article has been cited by other articles:
|
|
 |
|
  M. Li and J. N. Stallone Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1542 - H1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Homma, E. Hoy, D.-Z. Xu, Q. Lu, R. Feinman, and E. A. Deitch The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states Am J Physiol Gastrointest Liver Physiol, March 1, 2005; 288(3): G466 - G472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Horton, D. J. White, and D. L. Maass Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H202 - H213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Fulton and J. N. Stallone Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2062 - H2073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Stallone, R. L. Salisbury, and C. T. Fulton Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta J Appl Physiol, December 1, 2001; 91(6): 2602 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Nekooeian and C. C. Y. Pang Effects of estrogen on venous function in rats with chronic heart failure Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1941 - H1947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Huang, D. Sun, G. Kaley, and A. Koller Estrogen Maintains Nitric Oxide Synthesis in Arterioles of Female Hypertensive Rats Hypertension, June 1, 1997; 29(6): 1351 - 1356. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Greenstein, N. Jeffcote, D. Ilsley, and R.C. Kester The Menstrual Cycle and Raynaud's Phenomenon Angiology, May 1, 1996; 47(5): 427 - 436. [Abstract] [PDF]
|
|
|
|
 |
|
 D. GREENSTEIN, P. J. KENT, D. WILKINSON, and R. C. KESTER Raynaud's Phenomenon of Occupational Origin J Hand Surg Eur Vol., August 1, 1991; 16(4): 370 - 377. [PDF]
|
|
|
|
 |
|
 B. Altura, B. Altura, A Gebrewold, H Ising, and T Gunther Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ Science, March 23, 1984; 223(4642): 1315 - 1317. [Abstract] [PDF]
|
|
|
|
|
|
B. Altura, B. Altura, and A Gebrewold Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death Science, April 15, 1983; 220(4594): 331 - 333. [Abstract] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
