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Dopaminergic mechanisms of opiate actions in brain

E Eidelberg and R Erspamer

We have studied the interactions between morphine and a dopamine- blocking agent (haloperidol) and a dopamine precursor, L-3,4- dihydroxyphenylalanine (L-dopa). We found that haloperidol potentiated morphine-induced analgesia and enhanced morphine tolerance. Morphine- tolerant mice exhibited enhanced sensitivity to the locomotor excitatory actions of L-dopa. We propose that morphine exerts some of its central nervous actions by first interfering with dopamine-mediated synaptic transmission and then initiating compensatory changes that superficially resemble denervation supersensitivity. These compensatory changes may underlie the excitatory actions of morphine.

Volume 192, Issue 1, pp. 50-57, 01/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics




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 J PsychopharmacolHome page
A. Verma and S. K. Kulkarni
Modulatory role of D-1 and D-2 dopamine receptor subtypes in nociception in mice
J Psychopharmacol, January 1, 1993; 7(3): 270 - 275.
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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.