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Urinary excretion of morphine and its metabolites in morphine-dependent subjects

SY Yeh

Morphine, morphine glucuronide, morphine ethereal sulfate, normorphine and total normorphine in three consecutive 24-hour urines of four morphine-dependent subjects receiving morphine sulfate 60 mg s.c. q.i.d. have been determined with thin-layer chromatography and gas- liquid chromatography. With thin-layer chromatography the mean daily excretion of free morphine was 10% of the administered dose; morphine glucuronide, 65%; total (free and acid hydrolyzable conjugate) morphine 85%; and total normorphine, 3.5%. With gas-liquid chromatography, the percentage excretion for free morphine was 10%; total morphine, 74%; free normorphine, 1%; and total normorphine, 4%. The excretion of total drug was linearly related to the volume of the daily urine output.

Volume 192, Issue 1, pp. 201-210, 01/01/1975
Copyright © 1975 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics.