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Journal of Pharmacology And Experimental Therapeutics, Vol. 19, Issue 1, 97-130, 1922
Copyright © 1922 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF MORPHINE ON NORMAL CATS AND ON CATS DEPRIVED OF THE GREATER PART OF THE ADRENALS, WITH SPECIAL REFERENCE TO BODY TEMPERATURE, PULSE AND RESPIRATORY FREQUENCY AND BLOOD SUGAR CONTENT

G. N. STEWART 1 and J. M. ROGOFF 1

1 From the H. K. Cushing Laboratory of Experimental Medicine, Western Reserve University

The marked hyperthermia caused by morphine in cats (the rectal temperature increasing as much as 4°C.) has been studied in connection with the development of the general symptoms, the changes in the pulse and respiratory frequency, and the sugar content of the blood. It has been observed that there is no close association between the hyperthermia and the hyperglycemia, or even the degree of muscular activity. The hyperthermia and the general symptoms develop in the same way, and reach the same intensity in cats from which the greater portion of the adrenal tissue has been removed and the remaining fragment denervated, as in normal cats. Further experiments have been undertaken to show whether this is also true of the hyperglycemia.1

There is no foundation for the statement that adrenalectomised rats succumb to a very much smaller dose of morphine than normal rats.

Submitted on July 25, 1921






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Copyright © 1922 by the American Society for Pharmacology and Experimental Therapeutics.