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Journal of Pharmacology And Experimental Therapeutics, Vol. 188, Issue 2, 287-292, 1974
Copyright © 1974 by American Society for Pharmacology and Experimental Therapeutics

INCREASED LIVER MICROSOMAL ANDROGEN METABOLISM BY PHENOBARBITAL: CORRELATION WITH DECREASED ANDROGEN ACTION ON THE SEMINAL VESICLES OF THE RAT

W. Levin 1, R. M. Welch 1, and A. H. Conney 1

1 The Wellcome Research Laboratories, Burroughs Wellcome and Company, Tuckahoe, New York

Pretreatment of immature male rats with phenobarbital, a potent stimulator of microsomal testosterone hydroxylation, decreased the growth-promoting effect of an exogenously administered dose of testosterone, testosterone propionate, methyl testosterone or fluoxymesterone on the seminal vesicles. Feeding 0.01 to 0.1% phenobarbital in the diet for seven days, or for several months, decreased seminal vesicle weights, suggesting that phenobarbital may decrease the action of endogenously produced androgens by stimulating their metabolism. No effects of long-term phenobarbital administration on testicular weights were observed.

Submitted on June 6, 1973
Accepted on October 2, 1973




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Copyright © 1974 by the American Society for Pharmacology and Experimental Therapeutics.