JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fishman, J.
Right arrow Articles by Hellman, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fishman, J.
Right arrow Articles by Hellman, L.
Journal of Pharmacology And Experimental Therapeutics, Vol. 187, Issue 3, 575-580, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

DISPOSITION OF NALOXONE-7,8-3H IN NORMAL AND NARCOTIC-DEPENDENT MEN

Jack Fishman 1, Howard Roffwarg 2, and Leon Hellman 2

1 Institute for Steroid Research, Division of Psychiatry and Division on Oncology, Monteflore Hospital and Medical Center, Bronx, New York
2 Institute for Steroid Research, Division of Psychiatry and Division on Oncology, Monteforce Hospital and Medical Center, Bronx, New York

Naloxone-7,8-3H was administered intravenously and orally on separate occasions to the same normal male subject and its disposition was examined. The fate of intravenous naloxone-7,8-3H was also studied in an opiate-dependent subject both while on heroin maintenance and after withdrawal. In all cases the urinary excretioon was rapid but incomplete, nerve exceeding 70% of the dose over 72 hours. Initial plasma concentrations of naloxone were low with a rapid rate of disappearance. Oral naloxone entered plasma quickly but in metabolized form. The volume of distribution, plasma half-life and metabolic clearance rate of naloxone as calculated from the intravenous studies were about 200 liters, 90 minutes and 2500 liters/day, respectively.

Submitted on January 11, 1973
Accepted on August 3, 1973




This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
S. Krishnan-Sarin, M. I. Rosen, and S. S. O'Malley
Naloxone Challenge in Smokers: Preliminary Evidence of an Opioid Component in Nicotine Dependence
Arch Gen Psychiatry, July 1, 1999; 56(7): 663 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Palliat MedHome page
N. Sykes
An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer
Palliative Medicine, April 1, 1996; 10(2): 135 - 144.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. R. Cohen, R. M. Cohen, D. Pickar, H. Weingartner, and D. L. Murphy
High-Dose Naloxone Infusions in Normals: Dose-Dependent Behavioral, Hormonal, and Physiological Responses
Arch Gen Psychiatry, June 1, 1983; 40(6): 613 - 619.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
W. M. BENNETT, R. S. MUTHER, R. A. PARKER, P. FEIG, G. MORRISON, T. A. GOLPER, and I. SINGER
Drug Therapy in Renal Failure: Dosing Guidelines for Adults: Part I: Antimicrobial Agents, Analgesics
Ann Intern Med, July 1, 1980; 93(1_Part_1): 62 - 89.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
W. M. BENNETT, I. SINGER, T. GOLPER, P. FEIG, and C. J. COGGINS
Guidelines for Drug Therapy in Renal Failure
Ann Intern Med, June 1, 1977; 86(6): 754 - 783.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.