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Journal of Pharmacology And Experimental Therapeutics, Vol. 187, Issue 2, 365-371, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

beta-PHENYLETHYLAMINE: A SPECIFIC SUBSTRATE FOR TYPE B MONOAMINE OXIDASE OF BRAIN

H. -Y T. Yang 1 and N. H. Neff 1

1 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeth's Hospital, Washington, D.C.

beta-Phenylethylamine and serotonin were oxidatively deaminated by separate forms of monoamine oxidase of rat brain wimen studied in vitro. These forms, designated as type A and type B enzyme, have different characteristics. For example, type A enzyme deaminated serotonin, was sensitive to the drug clorgyline, was resistant to the drug deprenyl and was heat-stable. In contrast, type B enzyme deaminated beta-phenylethylamine, was resistant to clorgyline, was sensitive to deprenyl and was heat-labile. Moreover, type A and type B enzyme activities could be partially separated by centrifugation on a continuous sucrose gradient. beta-Phenylethylamine and serotonin are present in mammalian brain. We conclude from our studies that the amines of brain may be cataboblized by specific types of monoamine oxidase in vivo.

Submitted on March 21, 1973
Accepted on July 13, 1973




This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
M. A. Schwartz, R. J. Wyatt, H.-Y. T. Yang, and N. H. Neff
Multiple Forms of Brain Monoamine Oxidase in Schizophrenic and Normal Individuals
Arch Gen Psychiatry, October 1, 1974; 31(4): 557 - 560.
[Abstract] [PDF]


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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.