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Journal of Pharmacology And Experimental Therapeutics, Vol. 186, Issue 3, 609-615, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE STUDY OF THE ACTION OF PHENOTHIAZINE AND para-FLUOROBUTYROPHENONE DERIVATIVES ON RAT BRAIN MEMBRANES USING THE SPIN LABEL TECHNIQUE

F. LETERRIER 1, F. RIEGER 1, and J. F. MARIAUD 1

1 Division de Biophysique du Centre de Recherches du service de Santé des Armées, Institut de Biologic Physicochimique, Paris, France

The spin label technique reveals that phenothiazine and para-fluorobutyrophenone derivatives, such as haloperidol, modify the membrane proteic structure. Both types of drugs give qualitatively similar responses. Phenothiazine derivatives interact with all types of studied membrane material, but only the synaptic fraction is sensitive to the action of para-fluorobutyrophenone compounds. Some correlations can be made between the intensity of the spin label spectroscopic response and the pharmacological activity of the drugs.

Accepted on April 28, 1973






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