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Journal of Pharmacology And Experimental Therapeutics, Vol. 186, Issue 3, 425-429, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

TRANSFORMATION OF RAUSCHER VIRUS-INFECTED CELL CULTURES AFTER TREATMENT WITH HYCANTHONE AND LUCANTHONE

FRANK M. HETRICK 1 and WILLIAM L. KOS 1

1 Department of Microbiology, University of Maryland, College Park, Maryland

Rat embryo cell cultures (F 1706 line) chronically infected with Rauscher murine leukemia virus were transformed morphologically after treatment with low levels of the antischistosomal drugs hycanthone and lucanthone. Neither infection with the virus alone or treatment with the chemical alone resulted in the transformation. The foci of transformed cells appeared on the first subcultivation after chemical treatment and became the predominant cell as the cultures were passaged. In addition to their morphological change, the transformed cells no longer exhibited contact inhibition and they produced tumors within three to five weeks after implantation into newborn rats. Treatment of the virus-infected cells with known carcinogens also resulted in their transformation into cells with altered morphologies and invasive properties.

Submitted on January 11, 1973
Accepted on April 19, 1973




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P. B. Hulbert, P. E. Hartman, and E. Bueding
Hycanthone Analogs: Dissociation of Mutagenic Effects from Antischistosomal Effects
Science, November 15, 1974; 186(4164): 647 - 648.
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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.