JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PARKER, R. B.
Right arrow Articles by GOLDFINE, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PARKER, R. B.
Right arrow Articles by GOLDFINE, C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 185, Issue 3, 649-652, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

STOICHIOMETRY OF THE DRUG-NICOTINIC RECEPTOR INTERACTION

R. B. PARKER 1 and C. GOLDFINE 1

1 Naval Medical Research Iustitute, National Naval Medical Center, Bethesda, Maryland, and Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Appropriate estimation of drug-receptor dissociation constants with pharmacological techniques depends upon the stoichiometry of the reaction involved. The data presented in this paper suggest that both stimulant drugs and competitive antagonists interact on a one-to-one basis with the nicotinic receptor of the guinea-pig lumbrical muscle.

Submitted on August 31, 1972
Accepted on March 6, 1973






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.