JPET Assistant Professor of Medicine (Clinician-Educator)

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MARUYAMA, Y.
Right arrow Articles by TAKEMORI, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MARUYAMA, Y.
Right arrow Articles by TAKEMORI, A. E.
Journal of Pharmacology And Experimental Therapeutics, Vol. 185, Issue 3, 602-608, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF DOPAMINE AND NOREPINEPHRINE IN THE NALOXONE-INDUCED ABSTINENCE OF MORPHINE-DEPENDENT MICE

YUJI MARUYAMA 1 and A. E. TAKEMORI 1

1 Department of Pharmacology, University of Minnesota Health Sciences Center, Medical School, Minneapolis, Minnesota

Mice were made physically dependent by implantation with morphine pellets and then pretreated with various agents which are known to alter brain catecholamine levels before the stereotyped jumping was induced by naloxone. Disulfiram pretreatment decreased central norepinephnine (NE) levels by 46% and inhibited naloxone-induced jumping by 49%. agr-Methyltyrosine (agr-MT) pretreatment decreased NE by 73% and dopamine by 81% and inhibited the number of jumps by 89%. Pretreatment with 3-(3,4-dihydroxyphenyl)-L-alanine in addition to agr-MT restored the dopamine concentration and the numbers of jumps were increased 4-fold over those of mice pretreated with agr-MT alone. Pretreatment with threo-dihydroxyphenylserine in addition to agr-MT restored the NE concentration but the jumping was still inhibited by 90%. The full expression of abstinence syndrome in morphine-dependent mice appears to require the integrity of the central stores of NE and dopamine, especially the latter amine.

Submitted on September 25, 1972
Accepted on March 1, 1973




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
L. R. McMahon, S. L. Sell, and C. P. France
Cocaine and Other Indirect-Acting Monoamine Agonists Differentially Attenuate a Naltrexone Discriminative Stimulus in Morphine-Treated Rhesus Monkeys
J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 111 - 119.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.