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Journal of Pharmacology And Experimental Therapeutics, Vol. 185, Issue 3, 594-601, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

LACK OF RELATIONSHIP BETWEEN BRAIN (Na+ + K+)-ACTIVATED ADENOSINE TRIPHOSPHATASE AND THE DEVELOPMENT OF TOLERANCE TO ETHANOL IN RATS

TAI AKERA 1, RICHARD H. RECH 1, WILLIAM J. MARQUIS 1, THOMAS TOBIN 1, and THEODORE M. BRODY 1

1 Department of Pharmacology, Michigan State University, East Lansing, Michigan

The effects of chronic ethanol administration on brain (Na+ + K+)-activated adenosine triphosphatase were re-examined in rats. Despite the tolerance development to the behavioral depressant effects of ethanol as monitored by conditioned avoidance behavior and Rotarod performance, no remarkable change in (Na+, Mg++, ATP)-dependent binding of 3H-ouabain or (Na+ + K+)-activated adenosine triphosphatase activity of brain homogenates or microsomal fractions was observed after chronic ethanol treatments or during the subsequent withdrawal period. In contrast to a previous report, it was concluded that the (Na+ + K+)-activated adenosine triphosphatase is not related to the development of central tolerance to ethanol in rats.

Submitted on September 26, 1972
Accepted on February 26, 1973






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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.