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Journal of Pharmacology And Experimental Therapeutics, Vol. 185, Issue 3, 514-522, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

ESTROGEN-INDUCED BIOGENIC AMINE REDUCTION IN RAT UTERUS

THEODORE C. McKERCHER 1, LUCAS S. VAN ORDEN III 1, RANBIR K. BHATNAGAR 1, and JON P. BURKE 1

1 Department of Pharmacology, University of Iowa, Iowa City, Iowa

Estrogen-stimulated uterine hyperemia and edema have been reported to involve histamine. Fluorescence histochemical and electron microscopic examinations of uteri from ovariectomized rats given estradiol-17beta have revealed changes consistent with reduction of mast cell histamine and 5-hydroxytryptamine. Fluorometric assay showed that both amines were reduced to 65 to 70% of control values at one and four hours after estradiol administration. If these amine decreases represented release, they could account for the uterine edema observed at four hours after estradiol. The possibility exists that a nonmast cell histamine store may be implicated, but the present studies did not demonstrate such a store. Norepinephrine was decreased more rapidly than the other amines after estradiol administration, and fluorescence histochemical findings indicated that this change occurred in periarterial adrenergic nerves. These findings confirm and extend previous observations of biogenic amine reduction in response to small doses of estradiol and demonstrate cellular sites of such changes.

Submitted on August 7, 1972
Accepted on January 4, 1973




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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.