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1 The Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado
Norepinephrine (NE) causes a 4- to 6-fold rise in the cyclic 3', 5'-adenosine monophosphate content of chopped rat cerebral cortex. The effect is half-maximal at 6 µM and essentially maximal at 30 µM. The effect of 30 µM NE is only partially blocked by maximally effective concentrations (30 µM) of either propranolol or phentolamine. However, the effect is completely blocked when these inhibitors are added together even at lower concentrations (10 µM each). Isoproterenol (ISO) causes only a 2- to 4-fold rise in cyclic 3', 5'-adenosine monophosphate in the same preparation. The effect is half-maximal at 0.4 µM and essentially maximal at 3 µM. The effect of 30 µM ISO is completely blocked by 30 µM propranolol, but phentolamine is without effect. Maximally effective concentrations of NE and ISO together produce an effect similar to that of NE added alone. The results suggest that NE interacts with at least two types of receptors (analogous to alpha and beta) whereas ISO appears to react with a single type (analagous to beta). Analysis of the difference in the time courses of the effects of NE and ISO suggests that a slow component of the NE effect may be indirect.
Submitted on August 14, 1972
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