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Journal of Pharmacology And Experimental Therapeutics, Vol. 185, Issue 2, 177-184, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

SCHISTOSOME MOTILITY MEASUREMENTS: RESPONSE TO DRUGS

G. R. HILLMAN 1 and A. W. SENFT 1

1 Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island

An instrument is described which measures quantitatively and automatically the body movements of the human blood fluke, Schistosoma mansoni. The normal activity of this parasite shows a complex pattern of bursts of movement alternating with periods of lesser activity. The application of pentobarbital depresses activity; catecholamines and cyclic nucleotides have no effect. We also report the following findings, which confirm and extend earlier visual observations by other workers: serotonin stimulates activity up to 20-fold with immediate onset of action; 5-hydroxytryptophan stimulates by the same amount after a 45-minute delay; and carbamylcholine abolishes activity, and its effects cannot be reversed by serotonin. The instrumentation and methodology described afford a new method for studying effects of potential antischistosomal compounds and for evaluating schistosomes as a model system in neuropharmacology.

Submitted on July 5, 1972
Accepted on January 10, 1973




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