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Journal of Pharmacology And Experimental Therapeutics, Vol. 184, Issue 2, 449-452, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

MEASUREMENT OF GASTROINTESTINAL BLOOD LOSS IN THE RAT: THE EFFECT OF ASPIRIN, PHENYLBUTAZONE AND SECLAZONE

JEROME EDELSON 1 and J. F. DOUGLAS 1

1 Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, New Jersey

A practical procedure for the routine measurement of gastrointestinal bleeding in rats was developed. The technique is adapted from the chromium-51-labeled erythrocyte method used in humans. In this modification, we used homologous whole blood instead of autologous red cells. Comparison of several nonsteroidal anti-inflammatory agents tested under these conditions indicated that seclazone did not affect gastrointestinal blood loss whereas phenylbutazone and aspirin both induced gastrointestinal bleeding.

Submitted on April 17, 1972
Accepted on October 18, 1972






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