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Journal of Pharmacology And Experimental Therapeutics, Vol. 184, Issue 2, 385-397, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF CHLORPROMAZINE, PENTOBARBITAL, CHLORDIAZEPOXIDE AND d-AMPHETAMINE ON RATES OF LICKING IN THE RAT

WILLIAM C. KNOWLER 1 and THOMAS E. UKENA 1

1 Laboratory of Psychobiology, Department of Psychiatry; Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Times between successive lieks (interresponse times) were determined for rats licking water from a (drinking tube. The distribution of interresponse times during bursts of rapid licking was highly peaked and was stable over long periods of time and under different degrees of water deprivation. Dose-effect relations were determined for chlorpromazine, pentobarbital, chlomdiazepoxide and d-amphetamine on the mean and standard deviation of interresponse times and several other characteristics of the rats' drinking behavior. Both the mean and the standard deviation of interresponse times during bursts of rapid licking were increased by chlorpromzaine, pentobarbital and chlordiazepoxide. In contrast, d-amphetamine slightly decreased the means interresponse time at low doses and increased it at higher doses. Chlorpromazine and d-amphetamine caused a decrease in total volume of water conusumption. Chlordiazepoxide and low doses of pentobarbital increased water consumption, but higher doses of pentobarbital resulted in a decrease in volume cousumed.

Submitted on June 24, 1971
Accepted on October 10, 1972




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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.