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Journal of Pharmacology And Experimental Therapeutics, Vol. 184, Issue 1, 244-252, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

A STUDY ON THE MECHANISM OF VASOPRESSIN ESCAPE: EFFECTS OF CHRONIC VASOPRESSIN AND OVERHYDRATION ON RENAL TISSUE OSMOLALITY AND ELECTROLYTES IN DOGS

W. Y. CHAN 1

1 Department of Pharmacology, Cornell University Medical College, New York, New York

Vasopressin was administered daily with a forced water load to six trained dogs. Antidiuresis and natriuresis were observed in the dogs. After the initial few days of antidiuresis, vasopressin escape developed. The antidiuretic response to vasopressin became greatly reduced despite the continued administration of the hormone; natriuresis, however, remained. Vasopressin escape was found to develop only in the presence of chronic overhydration. In the absence of overhydration, daily administration of vasopressin for a much longer duration did not result in a loss of antidiuretic response to vasopressin. It was also found that vasopressin escape occurred independently of renal hemodynamic changes. Analyses of renal tissue osmolality and electrolytes revealed that kidneys from dogs with vasopressin escape had a marked loss of corticomedullary osmatic gradient. It is concluded that vasopressin escape results not from a prolonged exposure of the kidney tissue to the hormone but is related to a dissipation of corticomedullary osmotic gradient consequent to overhydration.

Submitted on April 24, 1972
Accepted on September 27, 1972




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Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics.