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Journal of Pharmacology And Experimental Therapeutics, Vol. 184, Issue 1, 155-162, 1973
Copyright © 1973 by American Society for Pharmacology and Experimental Therapeutics

MECHANISM OF ACTION OF PROPRANOLOL ON SQUID AXON MEMBRANES

CHAU H. WU 1 and TOSHIO NARAHASHI 1

1 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina

Propranolol blocks the action potential of the squid axon without affecting the resting potential. It suppresses the peak transient sodium conductance with a dissociation constant of 2.07 x 10-4 M and on a one-to-one stoichiometric basis. The curve relating the peak conductance to the membrane potential is shifted by propranolol in the direction of depolarization, and the time to peak current is shortened. However, the steady-state sodium inactivation curve is not affected. The steady-state potassium conductance is augmented by low concentrations of propranolol (1-3 x 10-5 M), whereas it is suppressed by higher concentrations. The significance of the increase in steady-state conductance induced by propranolol in its antiarrhythmic action is discussed.

Submitted on May 4, 1972
Accepted on September 19, 1972




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