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Journal of Pharmacology And Experimental Therapeutics, Vol. 182, Issue 2, 239-245, 1972
Copyright © 1972 by American Society for Pharmacology and Experimental Therapeutics

DISPOSITION OF HISTAMINE IN MAMMALIAN BLOOD VESSELS

RICHARD D. HOWLAND 1 and SYDNEY SPECTOR 1

1 Department of Physiological Chemistry, Pharmacology Section, Roche Institute of Molecular Biology, Nutley, New Jersey

Appreciable concentrations of histamine were found in the blood vessels of the rat and rabbit. In the rat, the aorta had the lowest concentration of histamine (1.6 µg/g), whereas the mesenteric artery and mesenteric vein had concentrations of 9.3 and 5.8 jµg/g, respectively. Histamine levels of rabbit aorta, mesenteric artery and renal artery ranged from 1.4 to 1.6 j. µg/g, whereas the inferior vena cava, mesenteric vein and renal vein contained 4.7 to 62 jµg/g of histamine. Reserpine did not affect the levels of histamine in the heart and arteries of the rat. On the other hand, compound 48/80 reduced histamine levels 75 to 85% in rat heart and vasculature. After the simultaneous administration of aminoguanidine and quinidine, histamine levels in the aorta, mesenteric artery and mesenteric vein were at least doubled eight hours after treatment. In contrast, no significant alterations of histamine concentration were seen in the heart, suggesting qualitative differences in disposition of histamine in vascular and cardiac tissue.

Submitted on October 5, 1971
Accepted on April 6, 1972




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Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics.