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Journal of Pharmacology And Experimental Therapeutics, Vol. 182, Issue 1, 83-92, 1972
Copyright © 1972 by American Society for Pharmacology and Experimental Therapeutics

PROPRANOLOL METABOLISM IN MAN AND DOG: MASS SPECTROMETRIC IDENTIFICATION OF SIX NEW METABOLITES

THOMAS WALLE 1 and THOMAS E. GAFFNEY 1

1 Division of Clinical, Pharmacology, Departments of Internal Medicine and Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio

The metabolism of oral propranolol has been studied in patients and dogs by gas chromatography-mass spectrometry. N-desisopropylpropranolol, 1-(agr-naphthoxy)-2,3-propyleneglycol, ring hydroxylated 1-(agr-naphthoxy)-2, 3-propyleneglycol, agr-naphthoxyacetic acid, agr-naphthol and 1,4-dihydroxynaphthalene were identified in urine as were unchanged propranolol and the earlier reported metabolites 4-hydroxypropranolol and naphthoxylactic acid. There were no qualitative differences between the patients and dogs. Several of these metabolites have pharmacological activity which may contribute to the diverse effects of propranolol in man.

Submitted on February 7, 1972
Accepted on April 3, 1972




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