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Journal of Pharmacology And Experimental Therapeutics, Vol. 181, Issue 1, 28-35, 1972
Copyright © 1972 by American Society for Pharmacology and Experimental Therapeutics

SEROTONIN TURNOVER IN THE INTACT CAT BRAIN

AMIRAM BARKAI 1, MURRAY GLUSMAN 1, and MAURICE M. RAPPORT 1

1 Department of Behavioral Physiology and Division of Neuroscience, New York State Psychiatric Institute and Departments of Psychiatry and Biochemistry; Columbia University College of Physicians and Surgeons, New York, New York

A new method of studying serotonin turnover in the brain that does not require assay of brain tissue is described: turnover is estimated from the rate of appearance (Rend) of endogenous 5-hydroxyindoleacetic acid in the perfused cerebrospinal fluid compartment. Studies of the effects of reserpine and probenecid on Rend in the anesthetized cat showed that reserpine caused an increase of about 50% in Rend whereas probenecid did not affect Rend under conditions where removal of 5-hydroxvindoleacetic. acid from the perfusate was inhibited. The perfusion method is suitable for studying changes in turnover in the same animal under various experimental conditions.

Submitted on August 27, 1971
Accepted on December 16, 1971






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Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics.