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Journal of Pharmacology And Experimental Therapeutics, Vol. 180, Issue 2, 501-513, 1972
Copyright © 1972 by American Society for Pharmacology and Experimental Therapeutics

IMMUNOPHARMACOLOGIC EFFECTS OF CYCLOLEUCINE

Marvin E. Rosenthale 1, Louis J. Datko 1, Jacob Kassarich 1, and Eugene I. Rosanoff 1

1 Immunoinflammatory Pharmacology and Virology Sections, Research Division, Wyeth Laboratories, Inc., Radnor, Pennsylvania

Cycloleucine (1-aminocyclopentane carboxylic acid) was shown to be quite active in preventing the clinical and histologic signs of experimental allergic encephalomyelitis and adjuvant arthritis. In contrast, it was inactive in two in vitro models designed to detect various types of clinically effective anti-inflammatory, anti-immune agents: tissue culture growth and polymorphonuclear leukocyte migration. Its immunopharmacologic spectrum differs from that of other clinically active agents, suggesting that it may work via a different mechanism or at a different site.

Submitted on May 21, 1971
Accepted on October 9, 1971






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