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Journal of Pharmacology And Experimental Therapeutics, Vol. 18, Issue 6, 455-465, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

THE RELATION OF HISTAMINE TO INTESTINAL INTOXICATION I. THE PRESENCE OF HISTAMINE IN THE HUMAN INTESTINE

JONATHAN MEAKINS 1 and CHARLES ROBERT HARINGTON 1

1 Department of Therapeutics, University of Edinburgh

1. The presence of histamine, in minute concentration, is demonstrated in the cecum (four cases) and in the transverse colon (two cases).

2. The formation of histamine is apparently not dependent upon the existence of intestinal obstruction, since it occurs several weeks after the obstruction has been removed.

3. Histamine could not be detected in the feces, whether there was intestinal disturbance or not; we regard this as probably due to the oxidation of this substance during the passage through the large intestine.

Submitted on July 13, 1921






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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.