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Journal of Pharmacology And Experimental Therapeutics, Vol. 18, Issue 5, 373-398, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF ANTISPASMODIC DRUGS ON THE BRONCHUS

DAVID I. MACHT 1 and GIU-CHING TING 1

1 From the Pharmacological Laboratory, Johns Hopkins University

1. A large number of drugs were studied in respect to their action on the bronchi by the "direct method," that is using excised surviving bronchial preparations of the pig.

2. Relaxation of bronchial muscle may be produced by drugs either through a direct action on the muscle cells themselves or on the sympathetic, parasympathetic or ganglionic terminal structures of the bronchi.

3. The most powerful broncho-dilators determined by the above method were firstly papaverin and various benzyl compounds which act on the muscle cells, secondly atropin which exerts its action through paralysis of the parasympathetic myoneural junctions, and thirdly epinephrin which produces active stimulation of the true sympathetic dilator terminals.

4. The iodid, bromid, and nitrite ions analytically studied produced a relaxation of the bronchial muscle. This effect, however, is probably considerably minimized in the intact body.

5. An interesting chemico-pharmacodynamic relationship which is of practical interest has been traced in connection with the action of various xanthin derivatives on the bronchial muscle.

6. The action of various antispasmodic drugs on bronchial muscle varies in intensity to some extent with the previous tonicity or spasticity of the bronchus.

7. A distinct difference in response to their reaction to drugs has been found to exist between the fresh surviving bronchi from healthy lungs on the one hand and lungs showing more or less pathological change on the other hand.

Submitted on June 15, 1921




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