THE EFFECT OF WATER DIURESIS ON THE ELIMINATION OF CERTAIN URINARY CONSTITUENTS

¹ From the Pharmacological Laboratory of Washington University School of Medicine, St. Louis, Missouri

The effect of water diuresis on the elimination of chlorides, creatinine, urea, ammonia, sulphates, phosphates, and carbonates has been studied in normal human subjects. The data obtained confirm the finding of Marshall in regard to urea, creatinine, and chlorides. Sulphates are increased in practica1ly all experiments. Ammonia and phosphates are generally increased, but may be unchanged. All of these substances are decreased in percentage. Carbonates (i. e., total carbon dioxide) are increased not only in absolute but in percentage amount. The hydrogen ion concentration of the urine is decreased during diuresis.

I wish to express my deep appreciation to Prof. E. K. Marshall, Jr., for his untiring interest and invaluable aid throughout the course of this investigation.

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