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Journal of Pharmacology And Experimental Therapeutics, Vol. 18, Issue 2, 103-110, 1921
Copyright © 1921 by American Society for Pharmacology and Experimental Therapeutics

THE PHYSIOLOGICAL ACTION OF N-METHYLHIS-TAMINE AND OF TETRAHYDROPYRIDO-3.4-IMINAZOLE ("IMIDAZOLISOPIPERIDIN" OF FRÄNKEL)

H. H. DALE 1 and H. W. DUDLEY. 1

1 Department of Biochemistry and Pharmacology, National Institute for Medical Research, Hampstead

N-Methylhistamine is found to have one two-hundredth of the activity of histamine on the blood-pressure, and about one eightieth of the activity on the uterus.

Fränkel and Zeimer ascribe a histamine-like physiological action to tetrahydropyrido-3-4-iminazole("imidazolisopiperidin") and state that it is much more powerful than histamine. Contrary to this statement it has been found that the above compound has only one fifteen-hundredth of the activity of histamine on uterine muscle, and practically no action on the blood-pressure.

Submitted on March 24, 1921




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Copyright © 1921 by the American Society for Pharmacology and Experimental Therapeutics.