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Journal of Pharmacology And Experimental Therapeutics, Vol. 179, Issue 1, 20-28, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF LATERAL HYPOTHALAMIC LESIONS ON UPTAKE OF NOREPINEPHRINE BY BRAIN HOMOGENATES

M. J. ZIGMOND 1, J. P. CHALMERS 1, J. R. SIMPSON 1, and R. J. WURTMAN 1

1 Department of Nutrition and Food Science, Massachusetts institute of Technology, Cambridge, Massachusetts; Harvard Medical School, Boston, Massachusetts

Uptake of norepinephrine-3H in vitro was reduced by approximately 50% in synaptosome-rich homogenates prepared from the ipsilateral telencephalon of rats with unilateral lesions of the lateral hypothalamus. A similar decline was observed in the endogenous concentration of norepinephrine in this area, in vitro uptake was reduced throughout the ipsilateral telencephalon, but was normal in homogenates from the contralateral side or from the brains of sham-operated animals. There was no change in the norepinephrine concentration or the in vitro uptake of norepinephrine in the brainstem. The reduction in norepinephrine-3H uptake by telencephalic homogenates was first evident 24 hours after placement of the lesion and was complete three days postoperatively. Uptake of the amino acid serine was not altered by hypothalamic lesions. Uptake of norepinephrine-3H by telencephalic homogenates was not affected by lesions of the central gray area of the mesencephalon that caused a 27% decrease in endogenous telencephalic serotonin concentration. This reduced in vitro uptake of norepinephrine demonstrates a specific functional interrelationship between the lateral hypothalamus and norepinephrine-containing nerve fibers throughout the telencephalon, one which may involve single fibers travelling through the hypothalamus to the telencephalon. This technique may prove useful in further studies of monoamine pathways in the central nervous system.

Submitted on January 28, 1971
Accepted on May 24, 1971




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