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Journal of Pharmacology And Experimental Therapeutics, Vol. 178, Issue 3, 541-548, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

BRONCHODILATOR ACTIVITY OF THE PROSTAGLANDINS E1 AND E2

MARVIN E. ROSENTHALE 1, ALPHONSE DERVINIS 1, and JACOB KASSARICH 1

1 Immuno-inflammatory Pharmacology Section, Wyeth Laboratories, Inc., Radnor, Pennsylvania

The prostaglandins PGE1 and PGE2 and isoproterenol were effective bronchodilators capable of reversing the increased airway resistance and decreased airway compliance induced by cholinergic stimulation in the cat. Administration of the prostaglandins by serosol greatly increased their potency compared with the i.v. route, whereas the converse was true of isoproterenol. Cardiovascular effects of PGE1 and PGE2 were prominent only after i.v. administration. Blockade of various neurologic pathways failed to affect the bronchodilating properties of PGE2. When administered by aerosol, the prostaglandins represent a new and novel class of potent bronchodilator agents.

Submitted on January 29, 1971
Accepted on May 13, 1971




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Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics.