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Journal of Pharmacology And Experimental Therapeutics, Vol. 178, Issue 1, 130-140, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF TOLBUTAMIDE ON BLOOD PRESSURE

JOHN K. WALES 1, ALISON M. GRANT 1, and FREDERICK W. WOLFF 1

1 Research Foundation of the Washington Hospital Center, and Division of Clinical Pharmacology, Department of Medicine, The George Washington University School of Medicine, Washington, D.C.

Tolbutamide caused a small increase in blood pressure in the dog. This effect was more marked after reduction of the blood pressure by various hypotensive agents. The increase caused by tolbutamide was still observed after elevation of a reduced blood pressure by norepinephrine, or angiotensin infusion. The effect was not associated with release of insulin brought about by tolbutamide; it was not mediated by catecholamine release, nor by an action of tolbutamide on the kidney. Possible mechanisms are discussed.

Submitted on December 17, 1970
Accepted on March 19, 1971






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Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics.