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Journal of Pharmacology And Experimental Therapeutics, Vol. 177, Issue 3, 591-599, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

RENAL EFFECTS OF URICOSURIC AGENTS IN THE CHIMPANZEE

G. M. FANELLI JR. 1, D. L. BORN 1, and S. S. REILLY 1

1 Merck Institute for Therapeutic Research, West Point, Pennsylvania

The renal effects of known uricosuric agents have been studied by standard clearance techniques in male chimpanzees. Probenecid, sulfinpyrazone and zoxazolaznine were orally active. Low doses of probenecid elicited a modest uricosuric effect suggesting that the renal transport of urate in this species may be more sensitive than that which obtains in man. Salicylate and carinamide were uricosuric; iodopyracet at high loads was also strongly uricosuric. Chlorothiazide administered i.v. produced a very transient increase in uric acid excretion similar to that seen in man.

Submitted on December 31, 1970
Accepted on March 1, 1971






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