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Journal of Pharmacology And Experimental Therapeutics, Vol. 177, Issue 3, 573-578, 1971
Copyright © 1971 by American Society for Pharmacology and Experimental Therapeutics

DAUNORUBICINOL, A MAJOR METABOLITE OF DAUNORTJBICIN: ISOLATION FROM HUMAN URINE AND ENZYMATIC REACTIONS

NICHOLAS R. BACHUR 1

1 Biochemistry Section, Laboratory of Pharmacology, Baltimore Cancer Research Center, National Institutes of Health, National Cancer Institute, Baltimore, Maryland

A major metabolite of daunorubicin from human urine and enzymatic reactions was isolated and characterized. Comparative data from thin-layer chromatography, infrared spectroscopy, mass spectroscopy and chemical derivatization of daunorubicin, adriamycin and the metabolite indicated the metabolite to be the 13-hydroxydaunorubicin, daunorubicinol. The hydrolytic product of daunorubicinol, daunorubicinol aglycone, was a second metabolite.

Accepted on February 16, 1971




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